Stevia‐based sweeteners offer a combination of favourable attributes for a dietary supplement: low calorie and high intensity. The major application of Stevia extracts and stevioside is their use as a sweetener and dietary supplement; this covers all aspects of artificial sweeteners (non‐sucrose) such as saccharin, aspartame, etc., as well as where sugar is used. Steviol glycosides as a food additive significantly enhance the palatability of food and drinks. In addition, stevioside can also be used in chewing gum, toothpaste and some cosmetics. This chapter provides different practical applications of Stevia extract in various forms. It discusses ethnomedical uses of Stevia in different parts of the world. Apart from the sweet content, Stevia rebaudiana constituents also offer therapeutic benefits, having antihyperglycaemic, antihypertensive, anti‐inflammatory, antitumour, antidiarrhoeal, diuretic and immunomodulatory effects.